Licochalcone E Present in Licorice Suppresses Lung Metastasis in the 4T1 Mammary Orthotopic Cancer Model

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Licochalcone E present in licorice suppresses lung metastasis in the 4T1 mammary orthotopic cancer model.

We investigated whether licochalcone E (LicE), a phenolic constituent of licorice, inhibits mammary tumor growth and metastasis using animal and cell culture models. 4T1 mammary carcinoma cells were injected into the mammary fat pads of syngeneic BALB/c mice. Starting 7 days after the injection, the mice received LicE (7 or 14 mg/kg body weight/day) via oral gavage for 25 days. LicE suppressed ...

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ژورنال

عنوان ژورنال: Cancer Prevention Research

سال: 2013

ISSN: 1940-6207,1940-6215

DOI: 10.1158/1940-6207.capr-13-0012